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Once pathological aetiologias have been discarded, it is relevant to question the supply and status of vitamins and minerals and to provide nutritional advice first aiming at promoting balanced food choices, then focusing on the use of vitamin and mineral supplementation

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Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation

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Essential metabolic can be impaired as a result of decreased mitochondrial activity brought on by low NAD+ levels

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